Senior Doctoral Fellow Speaker Series: Yiqing Lu & Amber Moore
Virtual via Zoom. Register to receive the Zoom link.
Event start date : 04/26/2023
Event end date : 04/26/2023
Event start time : 01:30 PM
Event end time : 03:00 PM
All sessions will take place virtually from 1:30-3:00 pm. Registrants will receive a Zoom link shortly after registering.
Learn about the rest of the Senior Doctoral Fellow Speaker Series.
YiQing Lu, Human Biology: “Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.”
Tumour suppressor p53 (TP53) is the most frequently mutated gene in all cancers. Several hotspot p53 mutants not only lose tumour suppressive capabilities, but also promote oncogenesis by gain-of-function mechanisms. p53 mutant proteins are often stabilised in tumours, which are vital for their oncogenic properties. Therefore, we aim to systematically uncover the cellular genetic networks that stabilise mutp53s, with the hope to destroy tumours by acting on those stabilisation networks. In this presentation, I shall discuss our innovative functional genomics and proteomics approaches to systematically uncover and functionally annotate these regulatory networks, both in cell lines and directly in mouse models. Ultimately, with ongoing drug screens, we hope to devise and improve precision medicine therapies to benefit patients with mutp53 related cancers. This work is carried out at Mount Sinai Hospital and the Weizmann Institute as a part of my doctoral thesis.
Amber Moore, Buddhism, Psychology & Mental Health: “Between Literary Worlds: Translation as commentary in the study of Newar Buddhist narratives.”
Amber will be discussing recent research and translations in the field of Buddhist studies of the Buddhist narrative entitled the Maniśailamahāvadāna which includes an origin story of the Buddhist Goddess Vajrayoginī. This is a multilingual compilation of both popular and lesser-known Buddhist narratives, māhātmyas and avadānas that have been translated into various Himalayan languages extant in only a few remaining Manuscripts in Nepal. Amber will discuss these manuscripts and their relationship to each other over the span of their linguistic variants in translation and commentary and from the perspective of translation as commentary, an inevidible result of epistemological crossing.